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Dulaglutide: a review in type 2 diabetes

After initial rapid loss (often 5-10 pounds in the first month, much of which is water weight), the rate of loss slows as metabolic adaptation occurs

Combining these medications amplifies fat oxidation and lean mass preservation, but only when titration is staggered, injection timing is optimised, and monitoring confirms both remain therapeutically effective

First, the analysis samples drawn from the DSP database represented a convenience sample of consulting patients with T2DM who used and/or discontinued a GLP1 RA, and the subgroup of patients who had discontinued a GLP1 RA in the past 6 months was relatively small